I have a 1998 Honda Accord, with the 2.4 liter 4 cyl. engine, and went thru this same problem. you may have to backtrack some to solve this issue. All coolant will reach a boiling point if not cooled down. some systems are intact, but inefficient, or have several small problems, showing up infrequently. I assume it runs ok up to a certain temperature , then overheats, and begins " spitting out fluid" ?. Can you see where approximately? As the coolant heats up it produces more pressure in the system, till it finds the weakest connection, and forces its way out, like steam out of a tea kettle.
Honda's have many small coolant lines, which can leak, causing coolant loss ,and eventually overheating. First, If your thermostat is new, and installed correctly, the upper and lower Radiator hoses should get warm during operation of the engine. If the upper hose is "HOT", and the lower hose is "COOL" then the thermostat is not opening, and your engine cant cool the liquid down, leading to overheating.. check thermostat for correct install, you can even take it back out and put it in hot water (160 degrees) to see if it does open. If so, its ok, the next main problem would be the radiator clogged, not allowing coolant to circulate from upper hose thru radiator to lower hose and back to engine. (so lower hose is cooler to the touch) . If both hoses are "HOT" then I would check the coolant Fans , mounted on the back of the radiator. At operating temp, they should kick on, even at idle. if they do not, they are at least contributing to the problem. check for power to fans. you can jumper a wire from battery right to them, they should come on. If not, fans bad, if jumpered power lets them come on then they are ok, look for wire interruption, breaks, cuts or find the fuse or rely controlling them, to check if bad .
My Honda Accord has small coolant lines running to the TPS on the back of the Intake manifold, impossible to see, and they can leak or be clogged. that alone would not cause massive coolant loss all at once though. It would be slow loss with poor idle of engine, till coolant is too low to be effective.
There is also a bigger coolant "pipe" or tube running across the back of the engine, from the water pump to the rear/ lower part of the thermostat housing, also impossible to see. Mine was corroded, and leaking. . that can be removed, replaced, or just the O ring rubber gaskets replaced at each end of it. It also has 2 hoses that come off of it as it crosses the back of the engine, they should be checked also. ( from under the car, with a bright little flashlight, you can see most all of these things.