Possible causes for these issues include dirty microSD card contacts, a faulty microSD card, or a faulty microSD port module. The following troubleshooting page link details the solutions for the aforementioned problems. 2012 Samsung Galaxy Note 10.1 Troubleshooting
If the distorted audio signal comes solely from the loudspeakers, it's possible that they are in disrepair and are due for a replacement, as detailed in the following troubleshooting page excerpt. 2012 Samsung Galaxy Note 10.1 Troubleshooting
Possible causes for a very poorly backlit display include a a mostly depleted battery charge, a faulty backlight, which would call for the replacement of the LCD screen, or faulty display connections (which can be checked using the bottom guide link). 2012 Samsung Galaxy Note 10.1 Troubleshooting